Table 2 GWAS on non-communicable diseases in African and recent African ancestry populations obtained from the National Human Genome Research Institute catalogue of published genome-wide association studies (GWAS)

Asthma

422 cases; 1,533 controls

3,750 white cases; 13,365 white controls; 592 white trios; 1,903 black cases; 2,432 black controls; 929 black family members

PDE4D

[55]

Asthma

464 African American cases; 471 African American controls; 1,028 African Caribbean family members

994 European descent cases; 1,243 European descent controls; 2,331 African descent cases, 2,874 African descent controls (includes family members)

NS

[56]

Asthma

793 European ancestry child cases; 1,988 European ancestry child controls

917 European ancestry child cases; 1,546 European ancestry child controls; 1,667 African American child cases; 2,045 African American child controls

DENND1B, CRB1

[54]

Asthma

2,088 European American cases; 1,612 African American and African Caribbean cases; 1,688 Latino cases

2,727 European American cases; 2,147 African American and African Caribbean case; 2,299 Latino cases

GSDMB, IL1RL1, TSLP, IL33, PYHIN1, C11orf71, CRCT1

[57]

Sickle cell anemia (severity)

177 African American severe patients; 1,088 African American mild patients

68 severe patients; 95 mild patients

NS

[58]

Sickle cell anemia (HbF modifiers)

2040 African American sickle cell anemia patients

NR

BCL11A, HBS1L-MYB

[59]

Podoconiosis

194 cases and 203 controls from Africa

202 family trios (two parents and one affected child) for family-based association testing; 94 cases and 94 controls for HLA-typing

HLA-DQA1

[60]